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The identification of single nucleotide polymorphisms (SNPs) in patients who have chronic

Abstract:
Background Occurring at a frequency of about one every 300 base pairs, SNPs are the most abundant form of genetic variation in the human genome. Every single one of us possesses a one-of-a-kind fingerprint made up of one of over 100 million SNPs. Methodology This study was carried out on 200 patients with chronic diseases that fulfilled the sampling criteria according to the research objective. Many chronic diseases included heart, blood pressure, diabetes, arthritis, and other diseases that were diagnosed clinically and through many tests. In contrast, there was another group of unaffected control people. Many tests were conducted for them, and after confirming these diseases, blood samples were drawn for genetic tests. Results the number of single nucleotide polymorphisms and their relationship to chronic diseases. The frequency of the genetic mutation (rs7903146) associated with the TCF7L2 gene was observed at a rate of 31 at the AA base and a risk ratio of 1.62 in people with diabetes, while the frequency of the mutation (rs10757274) associated with the CDKN2 gene was observed at a rate of 37 at the nitrogenous base. GG with a risk rate of 2.2 in people with heart disease. Finally, the rs2476601 mutation associated with the PTPN22 gene was repeated at a rate of 34% in TT with a risk rate of 2.1.

Keywords:
Single nucleotide polymorphisms (SNPs) , chronic diseases
Author (s): Reem K. Ibrahim ;.
Affilation: Department of Biology, College of Science, University of Anbar, Anbar, Iraq
Cite this article
Reem K. Ibrahim ,.,"The identification of single nucleotide polymorphisms (SNPs) in patients who have chronic",Journal of Positive Sciences, Issue:5, Volume(4), (2024) Page(54-59), ISSN:2582-9351.